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The quarantine buildings are the twin structures on the East side of Hydra Harbour between the Miaoulia Terrace and Historical Archive Museum of Hydra. The left building is now used as a community hall and exhibition centre, named for the Greek actress, Melina Mercouri, who was also the Minister of Culture in 1981. The other of the two buildings is now used as the home of the Hydra Voluntary Emergency Services (ground floor) and the offices of the Hellenic Coast Guard (port authorities).
The plague of 1792 killed a large part of the population, and many families temporarily moved away. As a result, the town was almost completely abandoned for a while.